- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- 【Updated on June 30, 2025】Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Understanding of molecular pathogenesis of T-cell leukemia by super-enhancer profiling
-
- SANDA Takaomi
- Cancer Science Institute of Singapore, National University of Singapore Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
Bibliographic Information
- Other Title
-
- スーパーエンハンサープロファイリングによるT細胞性白血病の分子病態の理解
- スーパーエンハンサープロファイリング ニ ヨル Tサイボウセイ ハッケツビョウ ノ ブンシ ビョウタイ ノ リカイ
Search this article
Description
<p>Super-enhancers comprise of clusters of enhancers that are typically defined by the ChIP-seq analysis for active histone marks. Although the biological significance of super-enhancers is still controversial, this concept is gaining prominence as useful characteristics of genes that play crucial roles in normal development and pathogenesis of cancer. In various cancer cells, super-enhancers are often associated with genes involved in carcinogenesis. For example, in T-cell acute lymphoblastic leukemia, the oncogenic transcription factor TAL1 and its regulatory partners (GATA3, RUNX1 and MYB) are regulated by super-enhancers; these genes are sensitive to transcriptional inhibition, for example, via the pharmacological approach using a small-molecule CDK7 inhibitor. This preferential inhibition of cancer genes can also be observed for other types of cancer. Based on these findings, we recently performed super-enhancer profiling combined with gene expression analysis in adult T-cell leukemia/lymphoma, which is a genetically complicated hematological malignancy, to identify critical genes responsible for the pathogenesis. This review article aims to discuss the concept of super-enhancers, their significance in biomedical research, and their potential utility in elucidating the molecular pathogenesis of cancer.</p>
Journal
-
- Rinsho Ketsueki
-
Rinsho Ketsueki 59 (7), 899-908, 2018
The Japanese Society of Hematology
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282763026925312
-
- NII Article ID
- 130007430320
-
- NII Book ID
- AN00252940
-
- ISSN
- 18820824
- 04851439
-
- NDL BIB ID
- 029187934
-
- PubMed
- 30078801
-
- Text Lang
- ja
-
- Article Type
- journal article
-
- Data Source
-
- JaLC
- NDL Search
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed