Stress-Vertigo/Dizziness Interaction

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  • Kai Ryota
    Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences
  • Sotoyama Hidekazu
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University
  • Nawa Hiroyuki
    Department of Molecular Neurobiology, Brain Research Institute, Niigata University
  • Horii Arata
    Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences

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Other Title
  • ストレス–めまい連関
  • ストレス-めまい連関 : 中枢メカニズムに関して
  • ストレス-メマイ レンカン : チュウスウ メカニズム ニ カンシテ
  • ―中枢メカニズムに関して―

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Abstract

<p>The most patients with dizziness complicate psychiatric disorder, especially anxiety disorder. Concerning the pattern as to which comes first dizziness or anxiety disorder, both were reported in the clinical observation. In this study, we investigated the interaction between dizziness and stress by using animal models. During hypergravity stimulation, vestibular information induced Fos protein expression as a marker of neural activation in the amygdala, which is the center of anxiety. Hypergravity also induced the gene expression of preprotachykinin, a precursor of substance P, in amygdala. Administration of the antagonist for NK-1 receptors inhibited nausea induced hypergrabity. These results suggest that vestibular stimulation activate the substance P neuronal system in amygdala and this activation would be related to the development of autonomic symptoms. On the other hand, social defeat stress did not affect the rotation behavior suggesting suffering dizziness although anxiety-like behaviors were increased.</p>

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