Does discontinuation of antithrombotics affect the diagnostic yield of small bowel capsule endoscopy in patients demonstrating obscure gastrointestinal bleeding?
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- Nakamura Shiro
- Department of Inflammatory Bowel Disease, Division of Internal Medicine, Hyogo College of Medicine
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- Watanabe Toshio
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Shimada Sunao
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Nadatani Yuji
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Otani Koji
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Tanigawa Tetsuya
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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- Miyazaki Takako
- Department of Inflammatory Bowel Disease, Division of Internal Medicine, Hyogo College of Medicine
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- Iimuro Masaki
- Department of Inflammatory Bowel Disease, Division of Internal Medicine, Hyogo College of Medicine
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- Fujiwara Yasuhiro
- Department of Gastroenterology, Osaka City University Graduate School of Medicine
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説明
<p>A large proportion of patients demonstrating obscure gastrointestinal bleeding (OGIB) are antithrombotic users and need to undergo small bowel capsule endoscopy (SBCE). We examined the effect of discontinuation of antithrombotics on the diagnostic yield of SBCE. Additionally, we assessed predictive factors associated with positive SBCE findings. Our study included 130 patients using antithrombotics who underwent SBCE for overt OGIB. The primary endpoint was the difference in the rate of positive SBCE findings between patients who continued and those who discontinued antithrombotics. Secondary endpoints were to investigate the effect of discontinuation of antithrombotics using a propensity score analysis, and to assess predictive factors associated with a positive SBCE. Among the 73 patients who continued use of antithrombotics, 36 (49.3%) patients demonstrated positive findings, while among the 57 patients who discontinued antithrombotics, 35 (61.4%) patients showed positive findings. Rates of positive SBCE findings didn’t differ between the two groups. After we performed propensity score matching, discontinuation didn’t affect the rate of positive SBCE findings. The lowest hemoglobin level was the only independent predictive factor associated with positive SBCE findings. In conclusion, discontinuation of antithrombotic therapy didn’t affect the diagnostic yield of SBCE in patients presenting with overt OGIB.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ
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Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ 63 (2), 149-153, 2018
一般社団法人 日本酸化ストレス学会
