Development of Vacuum-Ultraviolet Circular-Dichroism Spectrophotometer Using Synchrotron Radiation and Structural Analysis of Biomolecules

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  • MATSUO Koichi
    Hiroshima Synchrotron Radiation Center, Hiroshima University

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  • 放射光真空紫外円二色性分散計の開発と生体分子構造解析
  • ホウシャコウ シンクウ シガイエン ニショクセイ ブンサンケイ ノ カイハツ ト セイタイ ブンシ コウゾウ カイセキ

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Abstract

<p>A vacuum-ultraviolet circular-dichroism spectroscopy using synchrotron radiation greatly expands the utility of chiroptical technique for the structural analysis of biomolecules by combining with theoretical analysis and bioinformatics. This spectroscopy provides the structural dynamics, intramolecular hydrogen bonds, and hydrations of saccharides, and also successfully estimates the secondary structure contents, numbers of segments, and sequences of native proteins and non-native proteins such as membrane-bound proteins. The circular dichroism theory of protein discloses the local structures of the amyloid fibrils at the molecular level. This synchrotron-radiation spectroscopy is opening a new filed in the glycobiology and structural biology.</p>

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  • Nihon Kessho Gakkaishi

    Nihon Kessho Gakkaishi 60 (4), 200-208, 2018-08-31

    The Crystallographic Society of Japan

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