Combined therapy with gemcitabine hydrochloride and nanoparticle albumin-bound paclitaxel enabled resection in a patient with unresectable locally advanced pancreatic cancer

DOI Web Site 13 References Open Access
  • SAKAUE Takahiko
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine Center for Multidisciplinary Treatment of Cancer, Kurume University Hospital
  • FUKAHORI Masaru
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine Center for Multidisciplinary Treatment of Cancer, Kurume University Hospital
  • MIWA Keisuke
    Center for Multidisciplinary Treatment of Cancer, Kurume University Hospital Department of Surgery, Kurume University School of Medicine
  • USHIJIMA Tomoyuki
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine Center for Multidisciplinary Treatment of Cancer, Kurume University Hospital
  • YASUMOTO Makiko
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine
  • KURAOKA Kei
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine
  • ISHIDA Yuusuke
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine
  • NAGASU Sachiko
    Department of Surgery, Kurume University School of Medicine
  • ISHIKAWA Hiroto
    Department of Surgery, Kurume University School of Medicine
  • MIHARA Yuutarou
    Department of Pathology, Kurume University School of Medicine
  • NAKAYAMA Masamichi
    Department of Pathology, Kurume University School of Medicine
  • NAITOU Yoshiki
    Department of Pathology, Kurume University School of Medicine Department of Diagnostic Pathology, Kurume University Hospital
  • OKABE Yoshinobu
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine
  • TORIMURA Takuji
    Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine

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Other Title
  • Gemcitabine＋<i>nab</i>-Paclitaxel併用療法後に切除可能となった局所進行切除不能膵癌の1例

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Description

<p>A 70-year-old woman presented with worsening diabetes mellitus, and was found to have pancreatic cancer. The tumor was an unresectable locally advanced pancreatic cancer in contact with and invading more than 180 degrees of the superior mesenteric artery. Combined therapy with gemcitabine hydrochloride and nanoparticle albumin-bound paclitaxel (GEM+nab-PTX) was administered with measurable antitumor effects. After granting informed consent, subtotal pylorus-preserving pancreatoduodenectomy and portal vein resection were performed. Histopathologic findings showed that the effect of chemotherapy was grade 2 (Grading of histological response to preoperative therapy), and the surgical margins were histologically negative. Two years postoperatively, the patient is alive without recurrence. These findings suggest that the GEM+nab-PTX therapy for locally advanced pancreatic cancer enables radical resection of a previously unresectable tumor.</p>

Journal

  • Suizo

    Suizo 33 (4), 776-783, 2018-08-25

    Japan Pancreas Society

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