Characterization of Virucidal Activities of Chlorous Acid
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- Goda Hisataka
- Honbu Sankei Co. Ltd.
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- Ikeda Keiko
- School of Health and Nursing Science, Wakayama Medical University
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- Nishide Mitsunori
- Wakayama Shin-Ai Women's College
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- Nagao Tamiko
- Faculty of Nursing, Shikoku University
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- Koyama A. Hajime
- Department of Biology, Wakayama Medical University Graduate School of Medicine
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Abstract
<p>Virucidal effects of chlorous acid on enveloped and non-enveloped viruses were characterized. The virucidal activity was prominent in enveloped viruses. However, among non-enveloped viruses, viruses such as human rhinovirus and feline calicivirus showed a significant sensitivity to the reagent, whereas others such as poliovirus and coxsackievirus showed a weak sensitivity to the reagent, suggesting the presence of 2 classes of sensitivity to the reagent, among non-enveloped viruses. In addition, characterization of the mode of inactivation by the reagent revealed that virus inactivation is strongly dependent on virus species, contaminated proteins, and solvent system composition. Comparison of the cytotoxic effects of chlorous acid with those of sodium hypochlorite or sodium dodecyl sulfate (SDS) revealed that chlorous acid was similar to SDS and remarkably weaker than sodium hypochlorite. These results indicate the unique nature of chlorous acid as a potent virucidal agent with tolerable tissue damage, and reveal the merits and limitations of chlorous acid as a disinfectant in food hygiene and sanitizer in healthcare.</p>
Journal
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 71 (5), 333-337, 2018-09-30
National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee
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Details 詳細情報について
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- CRID
- 1390282763048458368
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- NII Article ID
- 130007485673
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- NII Book ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL BIB ID
- 029251377
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- PubMed
- 29709992
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed