The Effect of Immobilization on Muscle and Tendon Collagen Solubilities

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  • SUGAMA Satoshi
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kanazawa University
  • TACHINO Katsuhiko
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kanazawa University
  • HAIDA Nobuhide
    Department of Physical Therapy, School of Health Sciences, Faculty of Medicine, Kanazawa University

Bibliographic Information

Other Title
  • 関節固定が筋および腱組織コラーゲンの可溶性に及ぼす影響
  • 関節固定が筋および腱組織コラーゲンの可溶性に及ぼす影響 : ラットの筋・腱組織におけるコラーゲンの生化学的分析
  • ラットの筋・腱組織におけるコラーゲンの生化学的分析
  • Biochemical Studies on Collagen from Rat Muscle and Tendon Tissues

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Description

The purpose of this study was to investigate the change in solubility of 7 weeks immobilized Soleus muscle and Achilles tendon collagen. Left hind limb of six rats were immobilized for 7 weeks. Hydroxyproline was determined for the estimation of the collagen content in neutral salt soluble, acid soluble and insoluble collagen. In addition, insoluble collagen was digested with pepsin to determine solubility of insoluble collagen. In the case of Soleus muscle, collagen content to represent as a percent of wet weight was increased significantly during 7-week immobilization. In the case of Achilles tendon, collagen content to represent as a percent of wet weight did not change during the immobilization. In the case of Soleus muscle, the percentage of the salt solbule collagen to the total collagen was decreased significantly during 7-week immobilization. The percentage of the acid soluble and insoluble collagen to the total collagen did not change significantly during the immobilization. In the insoluble collagen, a rate of solubility with pepsin was decreased significantly. In the case of Achilles tendon, the percentage of the salt soluble collagen to the total collagen was decreased significantly during 7-weerk immobilization. The percentage of the acid soluble and insoluble collagen to the total collagen did not change significantly during the immobilization. In the insoluble collagen, a rate of solubility with pepsin did not change significantly. These results suggest that: 1) Solubility of Soleus muscle collagen, affected by intra and intermolecular crosslinks, changes during 7-week immobilization. 2) Solubility of Achilles tendon collagen, affected by intra and intermolecular cross-links, does not change remarkably during 7-week immobilization.

Journal

  • Physical Therapy Japan

    Physical Therapy Japan 23 (2), 72-79, 1996-03-31

    Japanese Society of Physical Therapy

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