Cellulose-derived charcoal binds to glyceraldehyde-driven advanced glycation end products in vitro

DOI
  • Nishino Yuri
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine

Bibliographic Information

Other Title
  • 高純度セルロース炭（ダイエタリーカーボンⓇ純炭粉末）は，グリセルアルデヒドに由来する終末糖化産物（AGE）を吸着する

Description

There is a growing body of evidence that formation and accumulation of advanced glycation end products (AGE) have progressed under diabetic conditions, thereby being involved in numerous diabetes-associated complications. Moreover, recently, food-derived AGE has been shown to play a role in the pathogenesis of aging-related disorders. In this study, we examined the binding affinity of cellulose-derived charcoal to glyceraldehyde-derived AGE, including methylglyoxal-derived hydroimidazolone (MG-H1) and glyceraldehyde-related pyridinium (GLAP). Cellulose-derived charcoal significantly adsorbed AGE-modified bovine serum albumin (AGE-BSA), MG-H1, and GLAP, but not non-glycated BSA in vitro. Activated charcoal nonspecifically adsorbed BSA. Our present study suggests that cellulose-derived charcoal might block the harmful effects of food-derived AGE on organ damage by inhibiting their intestinal absorption.

Journal

Details 詳細情報について

  • CRID
    1390282763050490240
  • DOI
    10.15634/j0100_0501_008
  • ISSN
    21887527
  • Text Lang
    ja
  • Data Source
    • JaLC
    • Crossref
    • OpenAIRE
  • Abstract License Flag
    Disallowed

Report a problem

Back to top