Propylthiouracil-induced Otitis Media with Antineutrophil Cytoplasmic Antibody-associated Vasculitis
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- Tanaka Rika
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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- Shimojima Yasuhiro
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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- Moteki Hideaki
- Department of Otorhinolaryngology, Shinshu University School of Medicine, Japan
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- Kishida Dai
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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- Ueno Ken-ichi
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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- Sekijima Yoshiki
- Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan
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説明
<p>We herein report a case of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) induced by propylthiouracil (PTU). A 30-year-old Japanese woman with Graves' disease, who was treated with PTU, reported with otitis media with sensorineural hearing loss bilaterally and trigeminal neuralgia on the left side, as well as elevated serum levels of myeloperoxidase-ANCA. Prior treatment with antibiotics was ineffective even after tympanostomy. However, clinical remission was immediately achieved after initiating prednisolone together with PTU withdrawal. These findings suggest that PTU therapy induces localized otological involvement as the concept of OMAAV. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 57 (20), 3029-3033, 2018-10-15
一般社団法人 日本内科学会