-
- TAKETANI Takeshi
- Department of Pediatrics, Shimane University Faculty of Medicine
Bibliographic Information
- Other Title
-
- 血液疾患における間葉系幹細胞の臨床応用
- ケツエキ シッカン ニ オケル カンヨウケイ カンサイボウ ノ リンショウ オウヨウ
Search this article
Abstract
<p>Mesenchymal stem cells (MSCs) perform multiple functions, such as immunomodulation and tissue repair, and they are also capable of differentiation into bone, cartilage, and fat cells. Furthermore, an MSC culture method has been established, and clinical safety is guaranteed; therefore, MSCs can be clinically applied for the treatment of many diseases. MSC treatment for hematological diseases is expected to be effective against refractory acute graft-versus-host disease (GVHD). It is presently used for treating chronic GVHD, preventing GVHD, promoting the engraftment of hematopoietic stem cells, and treating refractory aplastic anemia. However, owing to the cellular properties of MSCs, there are some concerns including increases in relapse, the deterioration of infectious diseases, and tumor formation or malignant transformation of MSCs. In the present review, I describe the present situation, problems, and prospects of the clinical application of MSCs for treating hematological diseases, including recent topics such as placental-derived decidual stromal cells and highly purified MSCs.</p>
Journal
-
- Rinsho Ketsueki
-
Rinsho Ketsueki 59 (10), 2362-2372, 2018
The Japanese Society of Hematology
- Tweet
Details 詳細情報について
-
- CRID
- 1390282763058839552
-
- NII Article ID
- 130007496702
-
- NII Book ID
- AN00252940
-
- ISSN
- 18820824
- 04851439
-
- NDL BIB ID
- 029282878
-
- PubMed
- 30305547
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed