A Study of Persistence of Anti-HBs Antibodies after Vaccination with Recombinant Hepatitis B Vaccine in Healthcare Workers

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  • IWASAKI Sumio
    Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital Infection Control Center, Hokkaido University Hospital
  • OYAMADA Reiko
    Infection Control Center, Hokkaido University Hospital
  • WATANABE Tsubasa
    Infection Control Center, Hokkaido University Hospital
  • HASUIKE Kiyomi
    Division of Hospital Safety Management, Hokkaido University Hospital
  • NAKAMURA Sumito
    Infection Control Center, Hokkaido University Hospital
  • YAMADA Takehiro
    Infection Control Center, Hokkaido University Hospital Division of Pharmacy, Hokkaido University Hospital
  • OBA Koji
    Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo
  • ISHIGURO Nobuhisa
    Infection Control Center, Hokkaido University Hospital

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Other Title
  • 医療従事者における組換え沈降B型肝炎ワクチン接種後のHBs抗体持続期間に関する検討

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<p>A total of 237 healthcare workers who had successfully acquired protective levels of anti-HBs antibodies (≥10 mIU/mL) by recombinant hepatitis B vaccine were followed up for a period of five years. Only 2.0% of the vaccinees who had acquired anti-HBs antibody levels of 10-49 mIU/mL four months after the third dose of vaccine had anti-HBs antibody levels higher than 10 mIU/mL five years later, and only 16.7% of the vaccinees who had acquired anti-HBs antibody levels of 50-99 mIU/mL four months after the third dose of vaccine had anti-HBs antibody levels higher than 10 mIU/mL five years later. On the other hand, 87.0% of the vaccinees who had acquired anti-HBs antibody levels of ≥400 mIU/mL four months after the third dose of vaccine had anti-HBs antibody levels higher than 10 mIU/mL five years later. Persistence of anti-HBs antibodies depends on the anti-HBs titer at four months after the third dose of recombinant hepatitis B vaccine.</p>

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