診断に苦慮した頸部Castleman病の2例

DOI Web Site Web Site 参考文献6件
  • 北嶋 達也
    昭和大学頭頸部腫瘍センター 昭和大学耳鼻咽喉科学講座
  • 池田 賢一郎
    昭和大学頭頸部腫瘍センター 昭和大学耳鼻咽喉科学講座 昭和大学歯学部口腔外科学講座口腔腫瘍外科学部門
  • 水吉 朋美
    昭和大学耳鼻咽喉科学講座
  • 内山 美緒
    昭和大学耳鼻咽喉科学講座
  • 洲崎 勲夫
    昭和大学耳鼻咽喉科学講座
  • 池谷 洋一
    昭和大学耳鼻咽喉科学講座
  • 平野 康次郎
    昭和大学耳鼻咽喉科学講座
  • 櫛橋 幸民
    昭和大学頭頸部腫瘍センター 昭和大学耳鼻咽喉科学講座 昭和大学歯学部口腔外科学講座口腔腫瘍外科学部門
  • 江川 峻哉
    昭和大学頭頸部腫瘍センター 昭和大学耳鼻咽喉科学講座 昭和大学歯学部口腔外科学講座口腔腫瘍外科学部門
  • 小林 一女
    昭和大学耳鼻咽喉科学講座
  • 嶋根 俊和
    昭和大学頭頸部腫瘍センター 昭和大学耳鼻咽喉科学講座 昭和大学歯学部口腔外科学講座口腔腫瘍外科学部門

書誌事項

タイトル別名
  • Two Cases of Cervical Castleman’s Disease that were Difficult to Diagnose
  • 臨床 診断に苦慮した頸部Castleman病の2例
  • リンショウ シンダン ニ クリョ シタ ケイブ Castlemanビョウ ノ 2レイ

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<p>Castleman’s disease was first reported by Castleman et al. in 1954 as a mediastinal lymph node hyperplasia similar to thymoma, and is a lymphoproliferative disease with a unique histology.</p><p>Subsequently, Keller et al. classified the disease into hyaline-vascular type and plasma cell type based on the histological features, however, the etiology of the disease is still unknown. Puncture suction cytology or needle biopsy alone is not sufficient for diagnosis, and it is considered difficult to diagnose before surgery, based on most past reports.</p><p>We report two cases of Castleman’s disease diagnosed after removal of a cervical mass under general anesthesia.</p><p>Case 1 was a 54-year-old male patient who underwent puncture aspiration cytology and open biopsy of the cervical mass, neither of which revealed a definitive diagnosis. In addition, the cervical mass was resected under general anesthesia for diagnostic purposes, because of the increase in the number/size of the nodules in both lungs. Histopathological examination revealed the diagnosis of Castleman’s disease, plasma cell type. Case 2 was a 36-year-old female patient who presented with a cervical mass. Preoperative examination failed to reveal a definitive diagnosis, and the mass was resected. Histopathological examination revealed the diagnosis of Castleman’s disease, hyaline-vasucular type. Castleman’s disease is difficult to diagnose before surgery. If examination/biopsy of the neck swelling does not lead to a diagnosis, it is thought that resection of the mass under general anesthesia or biopsy with sufficient sample volume should be performed. As cervical swelling may be the presenting manifestation of Castleman’s disease, it is necessary for otolaryngologists and head and neck surgeons to have adequate knowledge of the disease and its treatment. Castleman’s disease has been designated in Japan as an intractable disease since 2018, and diagnostic criteria have been proposed.</p>

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