- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Automatic Translation feature is available on CiNii Labs
- Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Idiopathic CD4-positive lymphocytopenia-associated progressive multifocal leukoencephalopathy confirmed by brain biopsy following negative results of repeated CSF-JC-virus tests: a case report
-
- Kano Yuya
- Department of Neurology, Tosei General Hospital
-
- Inoue Hiroyasu
- Department of Neurology, Nagoya City East Medical Center
-
- Sakurai Keita
- Department of Radiology, Teikyo University School of Medicine
-
- Yoshida Mari
- Medical Science of Aging, Aichi Medical University
-
- Miura Yoshiharu
- Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
-
- Nakamichi Kazuo
- Department of Virology 1, National Institute of Infectious Diseases
-
- Saijo Masayuki
- Department of Virology 1, National Institute of Infectious Diseases
-
- Yuasa Hiroyuki
- Department of Neurology, Tosei General Hospital
Bibliographic Information
- Other Title
-
- 髄液JCウイルス(JCV)-DNA PCR陰性で脳生検で診断した，特発性CD4陽性リンパ球減少症が関連した進行性多巣性白質脳症の1例
Search this article
Description
<p>A 75-year-old man presented with dysarthria and left facial paralysis. Brain diffusion-weighted MRI revealed a high-signal intensity in the right precentral gyrus, and he was hospitalized under the diagnosis of cerebral infarction. His symptoms worsened and brain MRI findings were consistent with progressive multifocal leukoencephalopathy (PML). Cerebrospinal fluid (CSF) JC virus (JCV) was undetectable in the DNA polymerase chain reaction (PCR) test four times, but brain biopsy revealed typical PML histopathology. He had no human immunodeficiency virus infection and history of immunosuppressive treatment, but he was found to have CD4+ lymphocytopenia. He was treated with mefloquine and mirtazapine, and died 29 months after symptoms onset. In cases whose repeated DNA PCR results are negative for CSF JCV, brain biopsy may be useful for the diagnosis of PML.</p>
Journal
-
- Rinsho Shinkeigaku
-
Rinsho Shinkeigaku 58 (12), 750-755, 2018
Societas Neurologica Japonica
