Non-IgE mediated Gastrointestinal Food Allergy by Shellfish

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  • Masukane Seiya
    Department of Pediatrics, Shimane University School of Medicine Department of Pediatrics, Matsue Red Cross Hospital
  • Haneda Yasuhiro
    Department of Pediatrics, Shimane University School of Medicine
  • Taketani Takeshi
    Department of Pediatrics, Shimane University School of Medicine

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  • 貝類による非IgE依存性消化管アレルギーの1例

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<p> A 10-year-old girl had several vomiting episodes 2 hours after eating corbicula. She tested weak positive for the short-neck clam-specific IgE. The skin prick test of corbicula was also negative. An allergen-specific lymphocyte stimulation test (ALST) by both the body and the broth of corbicula was positive. In particular, ALST by the broth in her serum showed a stronger response than that of healthy control. An oral challenge test with the corbicula soup induced vomiting 5 hours after ingestion. She was diagnosed with non-IgE mediated gastrointestinal food allergy due to corbicula. Removal of the shellfish was continued. She tested ALST after one year, and it remained positive. Oral challenge tests with body of corbicula and short-neck clam was negative, while broth of them induced vomiting 5 hours after ingestion. These suggest that common water-soluble antigen between corbicula and short-neck clam might be an inducer in patients with non-IgE mediated gastrointestinal food allergy.</p>

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