Synthetic Strategy toward Dearomatized Polycyclic Polyketide Natural Products

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  • 脱芳香化された多環性芳香族ポリケチド天然物の合成戦略
  • ダツホウコウカ サレタ タカンセイ ホウコウゾク ポリケチド テンネンブツ ノ ゴウセイ センリャク

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<p>Described herein are the synthetic strategies toward polyketide-derived polycyclic compounds decorated by post-functionalizations. The approaches are based on two key reactions, (1) annulation via benzonitrile oxide, and (2) benzoin cyclization, providing a linear tricarbocyclic intermediate with an angular hydroxy group. Also described are the stereocontrolled introduction of angular substituents via pinacol-type 1,2-shift and N-methylation-hydroxylation to pave the way to advanced intermediates. The synthetic utility of the approach has been highlighted by successful total syntheses of some structurally complex, polycyclic natural products.</p>

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