Streptococcus mitis/oralis Causing Blood Stream Infections in Pediatric Patients

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  • Basaranoglu Sevgen Tanır
    Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine
  • Ozsurekci Yasemin
    Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine
  • Aykac Kubra
    Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine
  • Aycan Ahmet Emre
    Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine
  • Bıcakcigil Asiye
    Department of Microbiology, Hacettepe University Faculty of Medicine
  • Altun Belgin
    Department of Microbiology, Hacettepe University Faculty of Medicine
  • Sancak Banu
    Department of Microbiology, Hacettepe University Faculty of Medicine
  • Cengiz Ali Bülent
    Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine
  • Kara Ates
    Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine
  • Ceyhan Mehmet
    Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine

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タイトル別名
  • <i>Streptococcus mitis</i>/<i>oralis</i> Causing Blood Stream Infections in Pediatric Patients

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説明

<p>Viridans streptococci are still under investigation concerning epidemiology, pathogenesis and clinical presentations. We aimed to investigate the clinical presentations and outcomes of pediatric patients infected with Streptococcus mitis/oralis. Based on the accumulation of bloodstream infections (BSI) caused by S. mitis/oralis in 4 patients in our Hematology and Bone Marrow Transplantation Department at a particular time, a review of the medical and microbiological records of pediatric patients with positive blood cultures for S. mitis/oralis in the entire hospital was performed. In addition, a retrospective case-control study was conducted. Pulsed-field gel electrophoresis of S. mitis/oralis in 4 patients displayed unrelatedness of the strains. A total of 53 BSI (42 BSI and 11 catheter-related BSI) were analyzed. Thirty-four percent of patients with BSI caused by S. mitis/oralis had febrile neutropenia. Clinical and microbiological outcomes were favorable and infection-related mortality was not observed. Although not significant, previous antibiotic use and trimethoprim-sulfamethoxazole prophylaxis were more common in the case group. S. mitis/oralis seems likely an important agent in bacteremic children who are particularly neutropenic because of the underlying hematologic and oncologic diseases. Prompt management of infections with appropriate antimicrobials, regarding antibiotic susceptibilities of organisms, may facilitate favorable outcomes.</p>

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