脳性巨人症患児および家族の皮膚紋理に関する検討 : I.手掌紋

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  • Studies on Dermatoglyphics in Children with Cerebral Gigantism and their Family Members

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Dermatoglyphic findings in 21 probands with cerebral gigantism (Sotos' syndrome) and in their parents and siblings (13 fathers, 18 mothers, 5 brothers, and 12 sisters) were compared with those in normal children (60 boys and 50 girls) to make a contribution to the elucidation of the etiology of cerebral gigantism. The followings were found to be characteristic for probands with cerebral gigantism. 1) The A line terminated at the base of the thumb. 2) Palmar alignment tended to be vertical. 3) The incidence of the third interdigital pattern was high. 4) Increased a-b ridge count was observed. 5) The high frequency of digital whorl pattern was noticed. 6) The total finger ridge count was increased. 7) The incidence of vestiges in thenar areas was high. 8) The incidences of ulnar arch, ulnar loop, and open field loop in hypothenar areas were high. The analysis on family members revealed the fact that they shared a part of the characteristics listed above; that is, the items 1), 2), 7), and 8) were significantly frequent in fathers, items 1), 2), 4), 5), 6), and a part of 8) in mothers, items 3), 6), 7), and 8) in brothers, and items 1), 2), 5), 6) and a part of 8) in sisters. A review of literature revealed 13 pedigrees in which a familial aggregation of cerebral gigantism patients was demonstrated. On the basis of the data here presented, the author concluded that a genetic factor might be involved in the eiology of this syndrome.

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