Successful treatment of mycosis fungoides (tumor stage) with low-dose oral etoposide in combination with local electron beam radiation therapy : Report of two cases

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  • TAKAHASHI Saki
    Department of Dermatology, Yokohama City University School of Medicine
  • WADA Hidefumi
    Department of Dermatology, Yokohama City University School of Medicine
  • HAKUTA Amiko
    Department of Dermatology, Yokohama City University School of Medicine
  • WATANABE Tomoya
    Department of Dermatology, Yokohama City University School of Medicine
  • KANBARA Takeshi
    Department of Dermatology, Yokohama City University Medical Center
  • MUKAI Yuki
    Department of Radiation Oncology, Yokohama City University School of Medicine
  • KOIKE Izumi
    Department of Radiation Oncology, Yokohama City University School of Medicine
  • AIHARA Michiko
    Department of Dermatology, Yokohama City University School of Medicine

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Other Title
  • 低用量エトポシド（VP-16）内服と局所電子線照射併用療法が著効した菌状息肉症腫瘍期の2例

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<p>We report two cases of mycosis fungoides (MFs).</p><p>Case 1 : A 66-year-old man was diagnosed with MF 40 years previously. At the age of 65 years, masses and ulcers appeared on his trunk, limbs, and eyelids. He was first treated with etretinate and narrow-band ultraviolet B phototherapy, which did not lead to any improvement.</p><p>Case 2 : A 66-year-old man was diagnosed with psoriasis 45 years previously. He was treated with corticosteroids, which maintained the symptoms well under control. However, he developed glaucoma, and the treatment was discontinued. Subsequently, the erythema on his trunk and face gradually spread, and tumors appeared.</p><p>We diagnosed both patients with MF (stage IIB) and treated them with low-dose oral etoposide and local electron beam radiation. This combination therapy markedly alleviated both the erythema and tumors within a few months. Although etoposide is a classical therapy, radiation in combination with etoposide is useful for the treatment of MF.[Skin Cancer (Japan) 2018 ; 33 : 179-184]</p>

Journal

  • Skin Cancer

    Skin Cancer 33 (3), 179-184, 2019

    The Japanese Skin Cancer Society

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