A Long-term Complete Response（CR）for More Than 10 Years with Chemotherapy in a Patient with Breast Cancer and Liver Metastases

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  • OSANAI Takayuki
    Department of Surgery, Tokyo Metropolitan Health and Medical Treatment Corporation, Ohkubo Hospital
  • SATO Eigo
    Department of Surgery, Tokyo Metropolitan Health and Medical Treatment Corporation, Ohkubo Hospital
  • TOMI Yoshiaki
    Department of Surgery, Tokyo Metropolitan Health and Medical Treatment Corporation, Ohkubo Hospital
  • MURAKATA Ayano
    Department of Surgery, Tokyo Metropolitan Health and Medical Treatment Corporation, Ohkubo Hospital
  • ODA Goshi
    Department of Breast Surgery, Tokyo Medical and Dental University

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Other Title
  • 化学療法にて10年以上CRを得ている乳癌肝転移の1例
  • 症例 化学療法にて10年以上CRを得ている乳癌肝転移の1例
  • ショウレイ カガク リョウホウ ニテ 10ネン イジョウ CR オ エテ イル ニュウガン カン テンイ ノ 1レイ

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A 53-year-old woman had a left breast mass at age 41 years noted by another physician, and further workup yielded a diagnosis of breast cancer (scirrhous carcinoma) : cT2 N1 (SLNB1/2) M0. She received neoadjuvant (preoperative) chemotherapy, underwent breast-conserving surgery, and then started adjuvant hormonal therapy (LHRH agonist + tamoxifen). At 1 year 5 months after starting hormonal therapy, a solitary 4-cm liver metastasis in S4 was noted. Anticancer therapy with weekly paclitaxel led to a complete response (CR), and then oral capecitabine was started at the patient's request. Currently, 12 years 9 months postoperatively (10 years 1 month after the liver metastasis was diagnosed), imaging studies have confirmed a long-term CR with no evidence of further metastases in any organ.<BR>In patients with oligometastases, even liver metastases in breast cancer, chemotherapy can have a favorable therapeutic effect in many cases. Oral anticancer drugs without established lifetime doses may help to maintain a long-term CR and should be considered as a therapeutic option.

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