Pomalidomideによる皮膚障害に対して脱感作療法が有効であった再発難治性多発性骨髄腫

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タイトル別名
  • Successful management of drug-induced skin rash in a relapsed multiple myeloma patient with pomalidomide desensitization
  • Pomalidomide ニ ヨル ヒフ ショウガイ ニ タイシテ ダツカンサ リョウホウ ガ ユウコウ デ アッタ サイハツ ナンチセイ タハツセイ コツズイシュ

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説明

<p>A 71-year-old man diagnosed with IgG-κ type multiple myeloma 11 years ago was treated with low doses of pomalidomide (POM, 1 mg/daily) and dexamethasone (20 mg/week) as the third-line of salvage regimen. The treatment was terminated 4 days later owing to the appearance of a severe skin rash, which had also occurred after previous treatment with lenalidomide. After 2 months, POM was readministered via an outpatient desensitization protocol under prednisolone administration. During five cycles of POM-treatment, no severe skin rash appeared, and partial remission was obtained even though the final POM dose was as low as 1 mg/day.</p>

収録刊行物

  • 臨床血液

    臨床血液 60 (2), 137-139, 2019

    一般社団法人 日本血液学会

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