Two cases of microscopic polyangiitis complicated with juvenile idiopathic arthritis

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  • Ohyama Rie
    Department of Pediatrics, Yokohama City University Graduate School of Medicine
  • Nishimura Kenichi
    Department of Pediatrics, Yokohama City University Graduate School of Medicine
  • Nakanaga Shiran
    Department of Pediatrics, Yokohama City University Graduate School of Medicine
  • Oohara Asami
    Department of Pediatrics, Yokohama City University Graduate School of Medicine
  • Hattori Seira
    Department of Pediatrics, Yokohama City University Graduate School of Medicine
  • Hara Ryoki
    Department of Pediatrics, Yokohama City University Graduate School of Medicine
  • Ito Shuichi
    Department of Pediatrics, Yokohama City University Graduate School of Medicine

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  • 顕微鏡的多発血管炎と多関節型若年性特発性関節炎を合併した2 小児例

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<p>Adult patients with ANCA-associated vasculitis (AAV) could be often complicated by other rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus but which is rare in children. We report two children with microscopic polyangiitis (MPA) complicated by Polyarticular RF-positive juvenile idiopathic arthritis. Case 1 was a 23-year-old female. She developed MPA at the age of 10. She had achieved remission by methylprednisolone pulse therapy (MPT) and intravenous cyclophosphamide. However, arthritis occurred 16 months later and she was diagnosed with pJIA. Methotrexate (MTX) was added and arthritis was resolved.</p><p>Case 2 was a 14-year-old female. She developed arthritis at the age of 11. She was diagnosed as having pJIA two years later. She was initially treated with prednisolone, MTX and etanercept. However, she presented hematuria and proteinuria at the age of 14 and was diagnosed with MPA. MPT combined with rituximab significantly ameliorated her symptom. Although concomitance of pJIA and AAV is quite rare, considering its possibility is important when patients developed unexpected clinical symptoms. Furthermore, it is important to choose of therapy which can simultaneously cover both-diseases, especially therapy for MPA is associate with the prognosis.</p>

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