過飽和溶液を利用したリン酸カルシウム成膜とバイオメディカル応用

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タイトル別名
  • Calcium Phosphate Coating Using Supersaturated Solutions for Biomedical Applications
  • カホウワ ヨウエキ オ リヨウ シタ リンサン カルシウムセイマク ト バイオメディカル オウヨウ

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<p>Calcium phosphate (CaP) coating on artificial materials helps to improve their biocompatibility and osteoconductivity. This review describes our biomimetic CaP coating processes using supersaturated CaP solutions. In the precursor-assisted biomimetic process, a substrate is initially pre-coated with amorphous CaP by alternately dipping in the calcium and phosphate solutions ; this is followed by the immersion of the substrate in a supersaturated CaP solution. This process effectively coats the entire surface of a porous material. In the laser-assisted biomimetic process, a substrate is irradiated using weak pulsed laser light in a supersaturated CaP solution. This process enables quick (<30 min) and area-specific CaP coating. By utilizing the aforementioned processes, various cell-stimulating substances, such as DNA, proteins, and trace elements, can be immobilized within the CaP coatings. Depending on the selection of cell-stimulating substances and processing conditions, the coatings can be designed to perform different biological functions. Our coating processes can be potentially used in several biomedical applications including bone tissue engineering and tooth surface modification.</p>

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  • 表面と真空

    表面と真空 62 (4), 217-222, 2019-04-10

    公益社団法人 日本表面真空学会

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