Physiological Effects and Organ Distribution of Bacillus amyloliquefaciens AS385 Culture Broth Powder Containing 1-Deoxynojirimycin in C57BL/6J Mice
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- PARIDA Isabella Supardi
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- TAKASU Soo
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- ITO Junya
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- IKEDA Ryoichi
- Food Research Laboratory, Asahimatsu Foods Co., Ltd.
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- YAMAGISHI Kenji
- Food Research Institute (NFRI), National Agriculture and Food Research Organization (NARO)
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- KIMURA Toshiyuki
- Food Research Institute (NFRI), National Agriculture and Food Research Organization (NARO)
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- MIYAZAWA Teruo
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University New Industry Creation Hatchery Center (NICHe), Tohoku University
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- EITSUKA Takahiro
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
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- NAKAGAWA Kiyotaka
- Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University
書誌事項
- タイトル別名
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- Physiological Effects and Organ Distribution of <i>Bacillus amyloliquefaciens</i> AS385 Culture Broth Powder Containing 1-Deoxynojirimycin in C57BL/6J Mice
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<p>1-Deoxynojirimycin (DNJ) has been known as a potent α-glucosidase inhibitor from mulberry leaves and considered beneficial in prevention of type 2 diabetes. Due to limited amount of DNJ in mulberry leaves, recent studies have focused in finding alternative source that can produce higher amount of DNJ. Previously, we produced a high DNJ-containing culture medium from Bacillus amyloliquefaciens AS385 and constructed a concentration method of bacterial culture medium using cation exchange column. However, less complicated concentration procedure is necessary to save time and cost during the large-scale production. Therefore, we developed a simpler concentration method using anion exchange resin to yield B. amyloliquefaciens AS385 culture broth powder (CBP; 1% DNJ) and evaluated the physiological effects of 5-wk dietary CBP intake in C57BL/6J mice. CBP intake tended to suppress the elevation of blood glucose level during oral glucose tolerance test. Moreover, CBP intake significantly lowered the fasting plasma glucose level and white adipose tissue mass. Next, we evaluated the absorption and distribution of DNJ in mice organs after daily CBP intake. We found detectable amount of DNJ in organs with intestine and kidney as the major targeted organs. We concluded that the DNJ content in CBP is absorbed from digestive tract, distributed and accumulated in organs, which most likely to contribute to the alteration of blood glucose regulation and adiposity in C57BL/6J mice. Our study was the first to report the physiological effects of CBP produced from B. amyloliquefaciens AS385 and the organ distribution of DNJ from CBP.</p>
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 65 (2), 157-163, 2019-04-30
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詳細情報 詳細情報について
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- CRID
- 1390282763110196480
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- NII論文ID
- 130007639824
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 029648252
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- PubMed
- 31061284
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可