Assessments of Biocompatibility of Root Canal Sealer Containing S-PRG Filler

DOI
  • Saori TANAKA
    Division of General Dentistry Center for Dental Clinics, Hokkaido University Hospital Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Faculty of Dental Medicine
  • Hirofumi MIYAJI
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Faculty of Dental Medicine
  • Erika NISHIDA
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Faculty of Dental Medicine
  • Saori MIYATA
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Faculty of Dental Medicine
  • Akihito KATO
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Faculty of Dental Medicine
  • Kayoko MAYUMI
    Department of Periodontology and Endodontology, Division of Oral Health Science, Hokkaido University Faculty of Dental Medicine
  • Toru TANAKA
    Department of Restorative Dentistry, Division of Oral Health Science, Hokkaido University Faculty of Dental Medicine
  • Satoshi INOUE
    Department of Clinical Education, Hokkaido University Faculty of Dental Medicine

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Other Title
  • S-PRGフィラー含有根管充塡用シーラーの生体親和性評価

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<p> Purpose: Surface pre-reacted glass-ionomer (S-PRG) fillers reportedly possess ion-releasing properties and exhibit bioactive effects. The purpose of this study was to evaluate the biocompatibility of a zinc oxide based sealer containing S-PRG fillers (S-PRG sealer) compared with zinc oxide eugenol (ZOE) and non eugenol (ZO) sealers.</p><p> Method: MC3T3-E1 cells were seeded on disks of S-PRG, ZOE and ZO sealers. Observations by scanning electron microscopy (SEM) and cell viability assay were carried out. Subsequently, each specimen was implanted into dorsal subcutaneous tissue of rats. After 10 and 35 days, the degree of inflammatory cell infiltration was evaluated by light microscopy using histological samples.</p><p> Results: SEM observation revealed cell proliferation on S-PRG sealer, but not on ZOE and ZO sealers. Cell viability on S-PRG sealer was significantly greater than that on ZOE and ZO sealers. At 10 days after implantation into rat subcutaneous tissue, all samples showed inflammatory cell infiltration, however, S-PRG sealer tended to cause a milder inflammatory response than ZOE and ZO sealers. Ten-day inflammation scores of S-PRG, ZOE and ZO sealers were 2.16, 2.67 and 2.83, respectively. At 35 days after implantation, inflammatory cells were rarely found around the S-PRG sealer. Inflammation scores of S-PRG, ZOE and ZO sealers at 35 days were 0.00, 0.67 and 0.67, respectively.</p><p> Conclusion: S-PRG sealer possesses superior biocompatibility compared to ZOE and ZO sealers.</p>

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