Anti-proliferative Activities towards Human Brain Glioma U251 Cells and Human Carcinoma Cells (KB3-1) of Some Twin-Drug Type Bivalent C₂-Symmetrical Phenylboronic Acid Derivatives
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- Furutachi Makoto
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Gondo Toshiaki
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Ikeda Ryuji
- Department of Pharmacy, University of Miyazaki Hospital
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- Yoshikawa Naoki
- Department of Pharmacy, University of Miyazaki Hospital
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- Yokota Tsubasa
- Department of Pharmacy, University of Miyazaki Hospital
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- Takeda Yasuo
- Kagoshima University Hospital
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- Yokomizo Kazumi
- Faculty of Pharmaceutical Sciences, Sojo University
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- Zhou Jian-Rong
- Faculty of Pharmaceutical Sciences, Sojo University
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- Kashige Nobuhiro
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Miake Fumio
- Faculty of Pharmaceutical Sciences, Fukuoka University
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- Sumoto Kunihiro
- Faculty of Pharmaceutical Sciences, Fukuoka University
書誌事項
- タイトル別名
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- Anti-proliferative Activities towards Human Brain Glioma U251 Cells and Human Carcinoma Cells (KB3-1) of Some Twin-Drug Type Bivalent <i>C</i><sub>2</sub>-Symmetrical Phenylboronic Acid Derivatives
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<p>Derivatives of C2-symmetrical bivalent phenylboronic acid exhibit several remarkable biological activities such as anti-herpes simplex virus (HSV)-1 and cytotoxic activities against Vero cells and they can reverse the effect of anticancer drugs. Novel symmetrical bivalent molecules were synthesized and their biological activities were evaluated in vitro using a human brain glioma cell line (U251) and a human carcinoma cell line (KB3-1). Among the tested compounds (1a–i), bivalent C2-symmetrical phenylboronic acid derivative 1g showed the highest anti-proliferative activity towards both U251 and KB3-1 cells. The values of 50% anti-proliferative activity (IC50) of this compound against the two cell lines (U251 and KB3-1) were 19.0 and 3.78 µM, respectively. The anti-proliferative activity of compound 1g towards KB3-1 cells was higher than that of cisplatin. The bivalent C2-symmetrical compound 1g had a linear methylene linker in the molecule.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 42 (5), 833-836, 2019-05-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282763112023552
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- NII論文ID
- 130007641479
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 029657884
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- PubMed
- 31061327
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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