Two Cases of Squamous Cell Carcinoma Arising on Refractory Skin Ulcers in Patients with a History of Hansen's Disease

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  • FUKAI Kyoko
    Department of Dermatology, Graduate School and Medicine, University of the Ryukyus
  • KOMATSU Kotaro
    Department of Dermatology, Graduate School and Medicine, University of the Ryukyus
  • MATSUO Yuji
    Department of Dermatology, Graduate School and Medicine, University of the Ryukyus
  • HAYASHI Kentaro
    Department of Dermatology, Graduate School and Medicine, University of the Ryukyus
  • KARIYA Yoshiyuki
    Department of Dermatology, Graduate School and Medicine, University of the Ryukyus
  • MIYAGI Takuya
    Department of Dermatology, Graduate School and Medicine, University of the Ryukyus
  • YAMAGUCHI Takuya
    Department of Dermatology, Graduate School and Medicine, University of the Ryukyus
  • TERUYA Misao
    Division of Dermatology, Natinal Sanatorium Okinawa Airakuen
  • TAKAHASHI Kenzo
    Department of Dermatology, Graduate School and Medicine, University of the Ryukyus

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Other Title
  • ハンセン病後遺症による難治性足潰瘍に生じた有棘細胞癌の2 例
  • 症例 ハンセン病後遺症による難治性足潰瘍に生じた有棘細胞癌の2例
  • ショウレイ ハンセンビョウ コウイショウ ニ ヨル ナンチセイ ソク カイヨウ ニ ショウジタ ユウキョクサイボウガン ノ 2レイ
  • Two cases of squamous cell carcinoma arising on refractory skin ulcers in patients with a history of Hansen’s disease [in Japanese]

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<p>Case 1 : An 87-year-old man was diagnosed as having L-type Hansen's disease at 18 years of age. He presented with a skin ulcer on the dorsal side of his left foot five years ago, which had gradually enlarged and developed a tumorous nodule. At his first visit to our hospital, he presented with a dome-shaped tumor on the dorsal side of his left foot. He was diagnosed with squamous cell carcinoma(SCC), and his left leg was amputated from below the knee. Case 2 : A 54-year-old man was diagnosed as having L-type Hansen's disease at 20 years of ago. He presented with a skin ulcer on his first toe when he was 43 years old. He was diagnosed with SCC at 47 years of age, and his right leg was amputated from below the knee. He had developed a callus on his left sole decades before, and a skin ulcer appeared on this callus when he was 52 years old. The skin ulcer expanded when he was 54 years old, and he was diagnosed with SCC. His left first, second, and third toes were then amputated. Three months after the operation, the tumor recurred from the postoperative wound and metastasized to the lung, and he died of the illness. Chronic refractory skin ulcers due to Hansen's disease can play a role in scar carcinogenesis. Considering the relatively poor prognosis of scar cancer, refractory ulcer due to peripheral neuropathy after Hansen's disease should be monitored carefully.</p>

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