書誌事項
- タイトル別名
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- Bone Marrow Toxicity of Doxorubicin (DXR) Encapsulated in Polyethylene Glycol-Coated Liposomes
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説明
<p>The bone marrow toxicity of doxorubicin (DXR) encapsulated in polyethylene glycol-liposome (DXR-PEG-Liposome) in rabbits was examined and compared with DXR encapsulated in conventional liposome (DXR-Liposome) and free DXR. The white cell counts and platelet counts were measured for 28 days following intravenous injection at a dose of 1, 3, or 5 mg/kg. At that time, serum lipid peroxides (LPO), creatine phosphokinase (CK-MB), body weight, and temperature were also measured. The myelotoxic level of DXR-PEG-Liposome as judged by white cell counts and platelet counts was less than that of free DXR. However, no significant differences were found between DXR-PEG-Liposome and DXR-Liposome. It was suggested that such low toxicity of DXR-PEG-Liposome is due to a low accumulation of DXR in bone marrow. The changes in LPO and CK-MB were not observed; neither were the losing weight and fever, even at high dose (5 mg/kg). These results suggest that DXR-PEG-Liposome has little toxicity for the bone marrow in clinical application.</p>
収録刊行物
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- 薬剤学
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薬剤学 59 (2), 51-56, 1999
公益社団法人 日本薬剤学会
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詳細情報 詳細情報について
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- CRID
- 1390282763115440768
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- NII論文ID
- 10009772213
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- NII書誌ID
- AN00266708
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- ISSN
- 21883149
- 03727629
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
