Substrate Recognition and Cleavage Mechanism of Intramembrane-Cleaving Protease

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  • HIZUKURI Yohei
    Institute for Frontier Life and Medical Sciences, Kyoto University

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  • 膜内切断プロテアーゼの基質認識・切断機構
  • マク ナイ セツダン プロテアーゼ ノ キシツ ニンシキ ・ セツダン キコウ

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Abstract

<p>Intramembrane-cleaving proteases (I-CLiPs) are a unique class of proteases, which catalyze proteolysis of target membrane proteins within the lipid bilayer. I-CLiPs are found in all kingdoms of life and are involved in various cellular processes such as stress responses, lipid homeostasis, induction of apoptosis and bacterial virulence. RseP, an Escherichia coli I-CLiP, plays a critical role in the extracytoplasmic stress response essential for bacterial survival. In this review, I will summarize the results of our recent studies on the structure and function of RseP and propose a model of the substrate recognition and cleavage by this peculiar protease.</p>

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  • Seibutsu Butsuri

    Seibutsu Butsuri 59 (2), 079-083, 2019

    The Biophysical Society of Japan General Incorporated Association

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