A Case of Somatic-Type Malignant Tumor with Isochromosome 12p Arising from a Mature Cystic Teratoma without Genetic Alteration
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- Nishimaki Haruna
- Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
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- Nakanishi Yoko
- Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
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- Nakao Takehiro
- Department of Obstetrics & Gynecology, Nihon University School of Medicine, Nihon University School of Medicine, Tokyo, Japan
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- Takada Shinichi
- Department of Obstetrics & Gynecology, Nihon University School of Medicine, Nihon University School of Medicine, Tokyo, Japan
Bibliographic Information
- Other Title
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- Case Report : A Case of Somatic-Type Malignant Tumor with Isochromosome 12p Arising from a Mature Cystic Teratoma without Genetic Alteration
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Abstract
Teratoma is the most common germ cell tumor (GCT) of the ovary. Recently, much has been learned regarding the pathogenesis of GCT from a molecular biology perspective. Based on molecular biological findings, 12p gain, and isochromosome 12p (i(12p)), unlike testicular postpubertal teratoma, most ovarian teratomas are derived from benign germ cells in a parthenogenetic-like process. Furthermore, it is known that somatic-type malignant tumors, such as cancer and sarcoma, rarely arise from dermoid cysts. Herein, we present the case of a patient diagnosed with a malignant neuroepithelial component arising from a mature teratoma. Fluorescence in situ hybridization (FISH) revealed that i(12p) was detected in the malignant component but was absent from the teratomatous portion.
Journal
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- Journal of Nihon University Medical Association
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Journal of Nihon University Medical Association 78 (1), 47-50, 2019-02-01
NIHON UNIVERSITY MEDICAL ASSOCIATION
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Keywords
Details 詳細情報について
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- CRID
- 1390282763118004608
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- NII Article ID
- 130007627704
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- NII Book ID
- AN0018408X
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- ISSN
- 18840779
- 00290424
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- NDL BIB ID
- 029570867
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed