Direct Formylation of Fluorine-Containing Aromatics with Dichloromethyl Alkyl Ethers
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- Warashina Takuya
- R&D, Iharanikkei Chemical Industry Co., Ltd.
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- Matsuura Daisuke
- R&D, Iharanikkei Chemical Industry Co., Ltd.
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- Kimura Yoshikazu
- R&D, Iharanikkei Chemical Industry Co., Ltd.
書誌事項
- 公開日
- 2019-06-01
- 資源種別
- journal article
- DOI
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- 10.1248/cpb.c19-00176
- 公開者
- 公益社団法人 日本薬学会
この論文をさがす
説明
<p>Formylations of fluorine-containing aromatic compounds with dichloromethyl alkyl ethers have been investigated. Dichloromethyl propyl ether and dichloromethyl butyl ether have been applied for the formylation of fluorine-containing anisoles to give the corresponding aldehydes in good yields. Application of these ethers is preferable to that of methyl ether, which is prepared from volatile methyl formate. Reaction of fluorine-containing phenols with these dichloromethyl alkyl ethers did not give salicylaldehyde derivatives, leading instead to corresponding aryl formates in high yields. A plausible mechanism is discussed.</p>
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 67 (6), 587-593, 2019-06-01
公益社団法人 日本薬学会
