Clinical Pharmacology Research for Promoting Individualized Cancer Chemotherapy

DOI Web Site Web Site PubMed 1 Citations 24 References Open Access

Bibliographic Information

Other Title
  • がん薬物療法の適正化推進に向けた臨床薬学的研究
  • Symposium Review がん薬物療法の適正化推進に向けた臨床薬学的研究
  • Symposium Review ガン ヤクブツ リョウホウ ノ テキセイカ スイシン ニ ムケタ リンショウ ヤクガクテキ ケンキュウ

Search this article

Description

<p>Cancer chemotherapy has progressed remarkably with conventional and molecular-targeted anticancer drugs as well as immune checkpoint inhibitors. However, adverse drug reaction (ADR) management remains a challenge in cancer chemotherapy. Therefore, improving the quality of medical care through clinical pharmacology research is warranted. Intravenous injection of bendamustine in patients with follicular or mantle cell lymphoma frequently causes venous irritation. Because the underlying mechanisms are not clear, we investigated the factors responsible for bendamustine-induced venous irritation. Based on the results of our analysis, we altered the administration regimen and observed that the incidence of venous irritation, which manifested in a concentration-dependent manner following conventional approaches, significantly decreased when following the modified regimen. Guidelines on the management of chemotherapy-induced nausea and vomiting recommend aprepitant, a selective neurokinin-1 (NK-1) receptor antagonist, 5-hydroxytryptamine 3 (5-HT3) receptor antagonists, and dexamethasone as prophylactic antiemetics. Pretreatment with high-dose chemotherapy before hematopoietic stem cell transplantation has extremely high emetogenic potential. This can be countered by using aprepitant in combination with conventional antiemetics. However, the safety and efficacy of such combinations are unexplored. Upon evaluation, we observed improved antiemetic effects without an increase in ADRs. At this symposium, I highlight the significance of clinical pharmacology research for promoting individualized cancer chemotherapy.</p>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 139 (6), 901-909, 2019-06-01

    The Pharmaceutical Society of Japan

Citations (1)*help

See more

References(24)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top