Immunological Aspects in Primary Cicatricial Alopecia

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  • ITO Taisuke
    Department of Dermatology, Hamamatsu University School of Medicine

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  • 瘢痕性脱毛症と免疫の接点
  • ハンコンセイ ダツモウショウ ト メンエキ ノ セッテン

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<p>　Primary cicatricial alopecia (PCA) is a group of intractable and uncommon hair loss disorders characterized by permanent hair follicle destruction. The pathogenesis of PCA is still not fully understood, and no evidence-based treatment has been established. For patients, permanent hair loss may cause mental stress and their quality of life is markedly reduced. PCA is classified into 3 groups based on the most representative pathological finding of scalp biopsy samples : lymphocytic, neutrophilic and mixed. In this session, representative types of PCA will be discussed based on immunological aspects. For example, frontal fibrosing alopecia may be caused by autoimmune attack on the bulge area. In order to establish an effective therapy, investigation of the pathogenesis of PCA is required.</p>

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