Long-Term Comparison of Platinum Chromium Everolimus-Eluting Stent vs. Cobalt Chromium Zotarolimus-Eluting Stent ― 3-Year Outcomes From the HOST–ASSURE Randomized Clinical Trial ―
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- Kim Chee Hae
- VHS Medical Center
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- Park Kyung Woo
- Seoul National University Hospital
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- Kang Jeehoon
- Seoul National University Hospital
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- Park Byoung-Eun
- Dankook University Hospital
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- Cha Kwang Soo
- Busan National University Hospital
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- Rhew Jay Young
- Presbyterian Medical Center
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- Jeon Hui-Kyung
- Uijeongbu St. Mary’s Hospital
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- Shin Eun-Seok
- Ulsan Hospital
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- Oh Ju Hyeon
- Samsung Changwon Hospital
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- Jeong Myung-Ho
- Chonnam National University Hospital
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- Kim Sanghyun
- Boramae Medical Center
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- Hwang Kyung-Kuk
- Chungbuk National University Hospital
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- Yoon Jung-Han
- Wonju Christian Hospital
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- Lee Sung Yun
- Inje University Ilsan Paik Hospital
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- Park Tae-Ho
- Dong-A Medical Center
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- Moon Keon Woong
- St. Vincent’s Hospital
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- Kwon Hyuck-Moon
- Gangnam Severance Hospital
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- Hur Seung-Ho
- Keimyung University Dongsan Medical Center
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- Ryu Jae-Kean
- Daegu Catholic University Medical Center
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- Lee Bong-Ryul
- Daegu Fatima Hospital
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- Park Yong Whi
- Gyeongsang National University Hospital
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- Chae In-Ho
- Seoul National University Bundang Hospital
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- Kim Hyo-Soo
- Seoul National University Hospital
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Abstract
<p>Background:There are limited data on the long-term outcome of platinum chromium-based everolimus-eluting stents (PtCr-EES) vs. cobalt chromium-based zotarolimus-eluting stents (CoCr-ZES).</p><p>Methods and Results:A total of 3,755 patients undergoing percutaneous coronary intervention (PCI) were randomized 2:1 to PtCr-EES or CoCr-ZES, and 96.0% of patients completed the 3-year clinical follow-up. The primary outcome was target lesion failure (TLF), defined as a composite of cardiac death, target vessel-related myocardial infarction (MI), and clinically-driven target lesion revascularization (TLR). At 3 years, TLF occurred in 5.3% and in 5.4% of the PtCr-EES and CoCr-ZES groups, respectively (hazard ratio 0.978; 95% confidence interval 0.730–1.310, P=0.919). There were no significant differences in the individual components of TLF. Routine angiographic follow-up was performed in 38.9% of the total patients. In a landmark analysis of the subgroup that had follow-up angiography, the clinically-driven TLR rate of CoCr-ZES was significantly higher than PtCr-EES group during the angiography follow-up period (P=0.009). Overall definite and probable stent thrombosis rates were very low in both groups (0.5% vs. 0.6%, P=0.677).</p><p>Conclusions:PtCr-EES and CoCr-ZES had similar and excellent long-term outcomes in both efficacy and safety after PCI in an all-comer population.</p>
Journal
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- Circulation Journal
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Circulation Journal 83 (7), 1489-1497, 2019-06-25
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390282763125895296
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- NII Article ID
- 130007666972
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 029762277
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- PubMed
- 31155604
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed