A Parameter to Identify Thin-walled Regions in Aneurysms by CFD

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  • Tanaka Kazutoshi
    Graduate School of Mechanical Engineering, Tokyo University of Science, Tokyo, Japan Research Center for Medical Science, Department of Innovation for Medical Information Technology, The Jikei University School of Medicine, Tokyo, Japan
  • Takao Hiroyuki
    Graduate School of Mechanical Engineering, Tokyo University of Science, Tokyo, Japan Research Center for Medical Science, Department of Innovation for Medical Information Technology, The Jikei University School of Medicine, Tokyo, Japan Department of Neurosurgery, The Jikei University School of Medicine, Tokyo, Japan
  • Suzuki Tomoaki
    Department of Neurosurgery, Tachikawa General Hospital, Nagaoka, Niigata, Japan
  • Fujimura Soichiro
    Graduate School of Mechanical Engineering, Tokyo University of Science, Tokyo, Japan Research Center for Medical Science, Department of Innovation for Medical Information Technology, The Jikei University School of Medicine, Tokyo, Japan
  • Suzuki Takashi
    Research Center for Medical Science, Department of Innovation for Medical Information Technology, The Jikei University School of Medicine, Tokyo, Japan
  • Uchiyama Yuya
    Graduate School of Mechanical Engineering, Tokyo University of Science, Tokyo, Japan Research Center for Medical Science, Department of Innovation for Medical Information Technology, The Jikei University School of Medicine, Tokyo, Japan
  • Ono Hiroshi
    Graduate School of Mechanical Engineering, Tokyo University of Science, Tokyo, Japan Research Center for Medical Science, Department of Innovation for Medical Information Technology, The Jikei University School of Medicine, Tokyo, Japan
  • Otani Katharina
    Siemens Healthcare K.K., Tokyo, Japan
  • Ishibashi Hiroaki
    Department of Neurosurgery, The Jikei University School of Medicine, Tokyo, Japan
  • Yamamoto Makoto
    Department of Mechanical Engineering, Tokyo University of Science, Tokyo, Japan
  • Murayama Yuichi
    Department of Neurosurgery, The Jikei University School of Medicine, Tokyo, Japan

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<p>Objective: Thin-walled regions of cerebral aneurysms are areas of risk for rupture, particularly during surgical procedures. Prediction of thin-walled regions before surgery can lead to safer treatment, avoiding interactions with thin-walled regions. It is considered that blood flow influences aneurysm wall thickness reduction. The objective of this study was to establish a parameter to accurately identify thin-walled regions using computational fluid dynamics (CFD) analysis.</p><p>Methods: The surgical field was photographed during craniotomy in 50 patients with unruptured middle cerebral artery aneurysms and red regions of the aneurysm wall were compared with the color of the parent vessel and defined as a thin-walled region. CFD analysis was performed and the distribution map of wall shear stress divergence (WSSD*) was compared to the surgical image of the cerebral aneurysms.</p><p>Results: The WSSDmax region and thin-walled region were coinciding in 41 (82.0%) of the 50 patients. There was a significant difference (P = 0.00022) between the patients with and without coincidence between the WSSDmax and thin-walled regions, and the threshold, sensitivity, specificity, and area under the curve (AUC) on receiver operating characteristic (ROC) analysis of WSSDmax were 0.230, 0.900, 0.875, and 0.883, respectively.</p><p>Conclusion: High-WSSD regions tended to be coinciding with thin-walled regions, suggesting that WSSDmax is useful to identify thin-walled regions of cerebral aneurysms.</p>

収録刊行物

  • 脳神経血管内治療

    脳神経血管内治療 13 (6), 241-249, 2019

    特定非営利活動法人 日本脳神経血管内治療学会

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