A Case of Hereditary Breast and Ovarian Cancer Syndrome with Serous Tubal Intraepithelial Lesions in Bilateral Fimbriae Resected by Laparoscopic Risk-reducing Salpingo-oophorectomy

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  • KASHIMA Hiroyasu
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • OKA Kenji
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • SHINAGAWA Manaka
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • YAMANAKA Sakura
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • ONO Motoki
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • TAKEUCHI Hodaka
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • IDA Koichi
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • HIGUCHI Shotaro
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • YAMADA Yasushi
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • KOBARA Hisanori
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • KIKUCHI Norihiko
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • MIYAMOTO Tsutomu
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine
  • TACHIBANA Ryota
    Department of Obstetrics and Gynecology, Iida Municipal Hospital
  • FUKUSHIMA Yoshimitsu
    Center of Medical Genetics, Shinshu University Hospital
  • KOSHO Tomoki
    Center of Medical Genetics, Shinshu University Hospital
  • IESATO Asumi
    Division of Breast, Endocrine and Respiratory Surgery, Department of Surgery (II), Shinshu University School of Medicine
  • ITO Ken-ichi
    Division of Breast, Endocrine and Respiratory Surgery, Department of Surgery (II), Shinshu University School of Medicine
  • ASAKA Shiho
    Department of Laboratory Medicine, Shinshu University School of Medicine
  • UEHARA Takeshi
    Department of Laboratory Medicine, Shinshu University School of Medicine
  • SHIOZAWA Tanri
    Department of Obstetrics and Gynecology, Shinshu University School of Medicine

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Other Title
  • 腹腔鏡下リスク低減卵管卵巣摘出術により両側卵管采に漿液性卵管上皮内病変が発見された遺伝性乳癌卵巣癌症候群の１例
  • フククウキョウ カ リスク テイゲンランカン ランソウ テキシュツジュツ ニ ヨリ リョウガワランカンサイ ニ ショウエキセイランカン ジョウヒ ナイ ビョウヘン ガ ハッケン サレタ イデンセイ ニュウガン ランソウ ガン ショウコウグン ノ 1レイ

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Abstract

A 42-year-old woman, gravida 1 para 1, was referred to our hospital on suspicion of hereditary breast and ovarian cancer syndrome (HBOC) due to her medical and family history. Genetic testing revealed a germline BRCA1 mutation. She was diagnosed with HBOC, and decided to undergo risk-reducing salpingo-oophorectomy (RRSO). There was no abnormal macroscopic finding in the pelvis and abdomen, and laparoscopic RRSO (LRRSO) was performed uneventfully. Pathological examination revealed mildly atypical epithelium with high p53 and low Ki-67 expression in fimbriae of the bilateral fallopian tubes and a diagnosis of serous tubal intraepithelial lesion (STIL).<br>Serous tubal intraepithelial carcinoma (STIC) is considered to be a premalignant lesion of ovarian serous carcinoma. In the present case, we found STIL, which is presumed to be a precursor lesion of STIC, in bilateral fimbrial epithelia of the fallopian tubes resected by LRRSO. Therefore, LRRSO is considered to be an effective prophylactic treatment for HBOC patients.

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