Whole-brain imaging analysis of animal models of neuropsychiatric disorders

DOI Web Site
  • Seiriki Kaoru
    Institute for Academic Initiatives, Osaka University Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Kasai Atsushi
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University
  • Hashimoto Hitoshi
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University Division of Bioscience, Institute for Datability Science, Osaka University

Bibliographic Information

Other Title
  • 全脳イメージング法を用いた精神疾患モデルマウスの機能評価
  • ゼン ノウ イメージングホウ オ モチイタ セイシン シッカン モデルマウス ノ キノウ ヒョウカ

Search this article

Description

The brain consists of various brain regions, and each brain region has specific functions such as motor regulation, sensory perception and cognitive function. Although a number of cellular mechanisms underlying brain functions have been revealed by focusing on specific local brain areas, systems analysis of the whole brain is a prerequisite to further understand the functional and anatomical relationships of the brain and their alterations in neuropsychiatric disorders. To illustrate whole-brain structural and functional maps at cellular and subcellular resolutions, whole-brain imaging techniques using fluorescent microscopy have been recently developed together with quantitative analysis methods for the whole-brain data. These state-of-the-art imaging analyses are currently used for brain-wide neuronal projection mapping, cell-type specific mapping and neuronal activation mapping, and such analyses are applicable to pathological studies using animal models of neuropsychiatric disorders. Unbiased and hypothesis-free comparison across the whole brain is expected to identify network mechanisms that regulate various neurobiological functions and dysfunctions.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top