原発検索に難渋した下顎骨中心性粘表皮癌例

DOI Web Site Web Site 参考文献6件
  • 櫻井 利興
    千葉大学大学院医学研究院耳鼻咽喉科・頭頸部腫瘍学 千葉県がんセンター頭頸科
  • 米倉 修二
    千葉大学大学院医学研究院耳鼻咽喉科・頭頸部腫瘍学
  • 山﨑 一樹
    千葉大学大学院医学研究院耳鼻咽喉科・頭頸部腫瘍学
  • 大熊 雄介
    千葉県がんセンター頭頸科
  • 佐々原 剛
    千葉県がんセンター頭頸科
  • 佐々木 慶太
    千葉県がんセンター頭頸科
  • 櫻井 大樹
    千葉大学大学院医学研究院耳鼻咽喉科・頭頸部腫瘍学
  • 花澤 豊行
    千葉大学大学院医学研究院耳鼻咽喉科・頭頸部腫瘍学
  • 岡本 美孝
    千葉大学大学院医学研究院耳鼻咽喉科・頭頸部腫瘍学

書誌事項

タイトル別名
  • A Case of Central Mucoepidermoid Carcinoma of the Mandible in which the Primary Site was Difficult to Locate
  • 臨床 原発検索に難渋した下顎骨中心性粘表皮癌例
  • リンショウ ゲンパツ ケンサク ニ ナンジュウ シタ カガクコツ チュウシンセイネンヒョウヒガンレイ

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<p>Mucoepidermoid carcinoma (MEC) is one of the most common malignant tumors of the salivary glands, and the tumor is composed of mucous, squamous and intermediate cells. However, primary intraosseous MEC is an infrequent condition, in which location of the primary site is often delayed. We report a case of central MEC of the mandible. A 39-year-old man was admitted to our hospital with swelling of the lymph nodes in the left submandibular region. While fine-needle aspiration cytology of the lymph node showed metastatic adenocarcinoma, the primary site could not be detected by computed tomography, magnetic resonance imaging, positron emission tomography or gastrointestinal endoscopy. We performed modified radical neck dissection, and the histopathological diagnosis was MEC. Three months later, slight swelling of the left mandibular molar resion was observed, and a biopsy revealed the diagnosis of squamous cell carcinoma. We then performed left hemimandibulectomy, retropharyngeal lymph node dissection and right modified radical neck dissection, followed by reconstruction using a rectus abdominis myocutaneous flap. The histopathological diagnosis was high-grade MEC, and most of the lesion was located within the mandible. Even though the patient received postoperative adjuvant concomitant chemoradiotherapy with cisplatin, lung metastasis was detected, and the patient died 1 month later. Although central MEC of the mandible is an unusual tumor, careful examination with attention paid to the mandible should be performed, especially for ceses with an occult primary lesion.</p>

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