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- OCHI Toshiki
- Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine Division of Immune Regulation, Proteo-Science Center, Ehime University
Bibliographic Information
- Other Title
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- 造血器腫瘍に対する革新的T細胞免疫療法
- ゾウケツキ シュヨウ ニ タイスル カクシンテキ Tサイボウ メンエキ リョウホウ
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Abstract
<p>With the emergence of cancer immunotherapy, T cells have played important roles in inducing antitumor responses. Many types of antitumor receptors, which possess tumor-binding sites and T-cell activation sites, have been developed. For example, genetically engineered T-cell receptor, chimeric antigen receptor, and bispecific antibody can help us to educate and activate T cells specific for certain tumors. To generate optimal antitumor receptors, (1) selection/distribution of tumor antigens, (2) affinity/specificity and cross-reactivity of antitumor receptors, and (3) T-cell activation signals delivered from antitumor receptors should be considered. Accordingly, we explain how antitumor receptors recognize target antigens and summarize the mechanisms for on-target/off-target reactivity induced by T cells redirected with antitumor receptors. Furthermore, we discuss how antitumor receptors can be optimized for the development of next-generation cancer immunotherapy.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 60 (7), 824-833, 2019
The Japanese Society of Hematology
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Keywords
Details 詳細情報について
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- CRID
- 1390282763132640512
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- NII Article ID
- 130007687999
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 029915088
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- PubMed
- 31391373
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed