Physics of Cell Differentiation from Landscape Perspective(Research)

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  • ランドスケープ描像で見る細胞分化の物理(最近の研究から)
  • ランドスケープ描像で見る細胞分化の物理
  • ランドスケープビョウゾウ デ ミル サイボウ ブンカ ノ ブツリ

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Abstract

We have studied the differentiation of mouse embryonic stem cell (ES cell) into either trophectoderm or primitive endoderm by simulating the relevant gene regulation network in silico. Our results suggest that the slowness of the transcriptional apparatus formation/dissolution for Nanog gene is critical for the heterogeneity of Nanog protein expression, as well as the discreteness of the cell state, which discriminates ES cell, trophectoderm and primitive endoderm.

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  • Butsuri

    Butsuri 70 (10), 765-769, 2015-10-05

    The Physical Society of Japan

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