Microtubule-Binding Proteins Support Synaptic Plasticity by Regulating Transport of NMDA Receptors

  • Takei Yosuke
    筑波大学医学医療系 解剖学・神経科学研究室,人間総合科学研究科感性認知脳科学
  • Hirokawa Nobutaka
    東京大学大学院医学系研究科 分子構造・動態・病態学講座

Bibliographic Information

Other Title
  • 微小管結合蛋白によるNMDA受容体輸送調節と神経可塑性
  • ビショウカン ケツゴウ タンパク ニ ヨル NMDA ジュヨウタイ ユソウ チョウセツ ト シンケイ カソセイ

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Description

<p>Neurons form a neural network and communicate with each other via their synapses. Synaptic accumulation of neurotransmitter receptors is necessary for efficient neurotransmission. A kinesin superfamily protein, KIF17, transports NMDA receptor subunit 2B in dendrites. KIF17 is essential for processes involved in neuronal plasticity, such as long-term potentiation and long-term depression. Lack of KIF17 in mice resulted in memory disturbances. Transport of NMDA receptors is regulated by phosphorylation and CREB-mediated upregulation of motor proteins and cargoes in an activity-dependent manner. NMDA receptor transport was also found to be supported by a complex of non-motor microtubule-associated protein, MAP1A, and post-synaptic protein, PSD-93. These multiple mechanisms for regulating NMDA transport support neuronal plasticity and brain function, such as learning and memory.</p>

Journal

  • KENBIKYO

    KENBIKYO 51 (1), 9-12, 2016-04-30

    The Japanese Society of Microscopy

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