Does Single-Particle Reconstruction Facilitate Pharma Drug Discovery?

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  • 単粒子構造解析は創薬に役立つか
  • タンリュウシ コウゾウ カイセキ ワ ソウヤク ニ ヤクダツ カ

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<p>Single-particle electron cryo-microscopy (cryo-EM), which unlike x-ray crystallography and electron crystallography does not need a crystallization step, is expected to be useful for drug discovery. Therefore, the Japan Agency for Medical Research and Development (AMED) has implemented a program of cryo-EM-especially single-particle cryo-EM-to support drug discovery. Single-particle cryo-EM provides an alternative method of structural analysis that might allow us to build atomic models of target molecules when crystallographic analysis cannot be applied. Moreover, the structural data obtained should be useful in structure-based drug design. Although atomic models obtained for important biological molecules by using single-particle cryo-EM continue to be reported in top journals, expectations still precede concrete results in the field of drug development. This paper explains the problems of single-particle cryo-EM in drug discovery, and it uses real examples to describe why drug development needs this structural information.</p>

Journal

  • KENBIKYO

    KENBIKYO 54 (3), 131-137, 2019-12-30

    The Japanese Society of Microscopy

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