Outcomes of Intervention by Multidisciplinary Antimicrobial Stewardship Team for Treating <i>Staphylococcus aureus</i> bacteremia

DOI Web Site 7 References Open Access
  • MITSUHASHI Tatsuro
    Infection control office, Aomori Prefectural Central Hospital Division of Diabetes Mellitus and Endocrinology, Aomori Prefectural Central Hospital
  • HIRANO Ryuichi
    Infection control office, Aomori Prefectural Central Hospital Division of pharmacy, Aomori Prefectural Central Hospital
  • OSANAI Katsuyoshi
    Infection control office, Aomori Prefectural Central Hospital Division of pharmacy, Aomori Prefectural Central Hospital
  • KITAZAWA Junichi
    Infection control office, Aomori Prefectural Central Hospital Division of Clinical Laboratory, Aomori Prefectural Central Hospital

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Other Title
  • 黄色ブドウ球菌菌血症治療におけるAntimicrobial Stewardship Team介入の効果

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<p>[Background] Staphylococcus aureus bacteremia (SAB) is known as an important nosocomial infection owing to its high mortality rate. We compared treatment items and survival rate among patients diagnosed with SAB pre- and post- to evaluate the effect of the intervention by the multidisciplinary antimicrobial stewardship team (AST) in our hospital.</p><p>[Methods] The intervention was implemented from April 2015. In total, 102 patients diagnosed with SAB were enrolled in this study: 50 patients enrolled between January 2014 and December 2014 comprised the pre-intervention group, and 52 patients enrolled between January 2016 and December 2016 comprised the post-intervention group.</p><p>We evaluated the survival rate and the achievement rate of the proposed bundles for patients with SAB using a hospital telephone as well as a tag function of an electronic medical chart provided by AST.</p><p>[Results] A significant difference was observed in the proportion of echocardiography procedures conducted to rule out infective endocarditis (pre-intervention, 22.5% vs. post-intervention, 75%), follow-up blood culture tests to confirm the clearance of bacteria (pre-intervention, 45% vs. post-intervention, 82.5%), and >14 days of therapy using antibiotics that exhibited susceptibility to the isolated bacteria (pre-intervention, 42.5% vs. post-intervention, 75%). No significant difference was observed in the 30-day survival rate (pre-intervention, 73.8% vs. post-intervention 74.4%).</p><p>[Conclusion] Our multidisciplinary intervention was efficient in implementing medical procedures required to evaluate complicated SAB. Although no significant difference was observed in the survival rate, our intervention without the board-certified membership of the Japanese Association for Infectious Diseases contributed to the improvement of process indicators among patients with SAB.</p>

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