Basic Study on Enhancement of Antioxidant Function by Low-dose Irradiation in Mouse Brain and Its Combined Effect with Ascorbic Acid
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- Kataoka Takahiro
- Graduate School of Health Sciences, Okayama University
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- Yunoki Yuto
- Last position, Graduate School of Health Sciences, Okayama University
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- Kanzaki Norie
- Last position, Graduate School of Health Sciences, Okayama University
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- Sasaoka Kaori
- Last position, Graduate School of Health Sciences, Okayama University
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- Kobashi Yusuke
- Graduate School of Health Sciences, Okayama University
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- Ishida Tsuyoshi
- Graduate School of Health Sciences, Okayama University
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- Hanamoto Katsumi
- Graduate School of Health Sciences, Okayama University
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- Yamaoka Kiyonori
- Graduate School of Health Sciences, Okayama University
Bibliographic Information
- Other Title
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- マウス脳における低線量照射による抗酸化機能の亢進とアスコルビン酸投与併用による複合効果の基礎的検討
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Abstract
<p>We studied on the characteristics of changes in antioxidant function of mice brains at 4 h to 7 days after low-dose X-ray (0.1 to 2.0 Gy) irradiation, and the combination effect of this and administration of ascorbic acid (500 mg/kg body weight), an antioxidant enzyme. As a result, low-dose irradiation mostly showed decrease in lipid peroxide levels, increase in superoxide dismutase (SOD) activities and heat shock protein (HSP) levels. In addition, the combined use of 0.5 Gy irradiation with ascorbic acid administration showed a significant decrease in lipid peroxide level, suggesting the combined effect of antioxidant.</p>
Journal
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- RADIOISOTOPES
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RADIOISOTOPES 69 (2), 45-53, 2020-02-15
Japan Radioisotope Association
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Keywords
Details 詳細情報について
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- CRID
- 1390283659852128128
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- NII Article ID
- 130007798435
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- NII Book ID
- AN00351589
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- ISSN
- 18844111
- 00338303
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- NDL BIB ID
- 030263297
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed