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The utility of polymerase chain reaction (PCR) for early diagnosis of syphilis in female patients
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- Hamada Takashi
- Shinjuku Ladies Clinic
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- Kugishima Yukari
- Shinjuku Ladies Clinic
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- Watanabe Mayu
- Shinjuku Ladies Clinic
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- Bukeo Maiko
- Shinjuku Ladies Clinic
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- Kowata Yuki
- Shinjuku Ladies Clinic
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- Okazaki Narumi
- Shinjuku Ladies Clinic
Bibliographic Information
- Other Title
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- 女性の梅毒患者の早期診断におけるPCR検査の有用性についての検討
- ジョセイ ノ バイドク カンジャ ノ ソウキ シンダン ニ オケル PCR ケンサ ノ ユウヨウセイ ニ ツイテ ノ ケントウ
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Description
A retrospective examination of 41 female patients diagnosed with primary and secondary syphilis using serological tests and polymerase chain reaction (PCR) was performed. Of the total, 25 patients had positive results in both serological and PCR tests, whereas 6 were positive only in serological tests, indicating a false-negative result obtained by PCR. The remaining patients had a positive result only in PCR and were suspected to have been tested during the serological latency period soon after Treponema pallidum infection. False-negative diagnoses can be minimized by standardizing the sample collection method for PCR and by becoming familiar with the methods used. In general, female patients notice genital lesions less often than male patients. A total of nine cases diagnosed during serological latency period had lesions with spontaneous pain. These symptoms brought the patients to the clinic. We conclude that combining PCR with serological tests is useful in diagnosing female primary syphilis and contributes to the prevention of syphilis transmission.
Journal
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- 日本性感染症学会誌
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日本性感染症学会誌 30 (1), 95-100, 2019-10-29
Japanese Society for Sexually Transmitted Infections
