Primary leptomeningeal lymphoma with oculomotor paralysis as the initial presentation

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  • 動眼神経麻痺にて発症した原発性軟髄膜リンパ腫
  • 症例報告 第10回日本血液学会関東甲信越地方会 優秀演題 動眼神経麻痺にて発症した原発性軟髄膜リンパ腫
  • ショウレイ ホウコク ダイ10カイ ニホン ケツエキ ガッカイ カントウ コウシンエツチホウカイ ユウシュウ エンダイ ドウガン シンケイ マヒ ニテ ハッショウ シタ ゲンパツセイナンズイマク リンパシュ

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Abstract

<p>An 85-year-old man presented with right eye ptosis and visual abnormalities. Due to a lack of abnormal findings on plain magnetic resonance imaging (MRI) and laboratory examination, prednisolone therapy was initiated, and ocular myasthenia gravis and ocular symptoms subjectively improved. However, anorexia and conscious disorder appeared during the same period, and he was hospitalized for scrutiny. After admission, left eye adduction disorder and bilateral abduction nerve paralysis were also observed. Enhanced MRI revealed cranial nerve and leptomeninx enhancement. Subsequently, the patient developed seizures and died on the 10th day of hospitalization without being diagnosed. An autopsy revealed infiltration of B-cell lymphoma cells into the subarachnoid space, particularly in the parietal lobe. Similar infiltration was observed in the cerebellum, brainstem, spinal cord, and bilateral oculomotor nerve. Primary leptomeningeal lymphoma is a rare form of primary central nervous system lymphoma without simultaneous parenchymal brain lesions. Clinicians should be aware of this form of lymphoma and carefully monitor its possible occurrence, even when patients are already being treated for other neurological diseases.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 61 (2), 116-121, 2020

    The Japanese Society of Hematology

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