Development of non-invasive drug and biomedicine delivery technologies based on the physiological nose-to-brain routes
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- Kanazawa Takanori
- Lab. Pharmaceutics, Sch. Pharm, Nihon Univ.
Bibliographic Information
- Other Title
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- 鼻腔-脳の生理学的ルートを基盤とする中枢組織への非侵襲的な薬物・バイオ医薬デリバリー技術の開発
Abstract
<p>The blood-brain barrier (BBB) poses a major challenge to the drug development efforts targeting brain/central nervous system (CNS) diseases, since it limits the distribution of systemically administered therapeutics to the brain/CNS. Therefore, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both clinical and pharmaceutical fields. Intranasal administration has been noted as a method of non-invasive delivery of a drug to the brain/CNS by bypassing the BBB via the nose-to-brain route. This "nose-to-brain" delivery system has the potential to be highly versatile, and a combination of this system with the new drug and biomedicine, which is thought to show promise in the treatment of CNS diseases. In addition, nano-sized drug carriers can improve nose-to-brain delivery.</p><p>In this seminar, we introduce overview of nose-to-brain delivery and our developed cell penetrating Tat peptide-modified block copolymer micelles (PEG-PCL-Peptide) for improvement of mucosal permeability and nose-to-brain transport efficiency. </p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 93 (0), 2-MS3-, 2020
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390283659859274752
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- NII Article ID
- 130007811537
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed