Blockade of endothelin ET<sub>B</sub> receptor ameliorates brain edema by regulation of astrocyte-derived factors after traumatic brain injury in mice
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- Michinaga Shotaro
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Nakaya Ryusei
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Fukutome Chihiro
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Minato Yukiko
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Inoue Anna
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Iwane Aya
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Tanabe Ayami
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Tujiuchi Yu
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Miyake Daisuke
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Yamamoto Hayato
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Ryu Ryotaro
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Mizuguchi Hiroyuki
- Dept. Pharmacol., Fac. Pharm., Osaka Ohtani Univ.
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- Koyama Yutaka
- Dept. Pharmacol., Kobe Pharmaceutical Univ.
Bibliographic Information
- Other Title
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- エンドセリンET<sub>B</sub>受容体拮抗薬による アストロサイト由来因子の発現調節を介した頭部外傷後の脳浮腫に対する抑制効果
Abstract
<p>Brain edema is a critical condition resulted from blood-brain barrier (BBB) disruption after traumatic brain injury (TBI). Several astrocyte-derived factors are involved in BBB function. We previously confirmed the involvements of endothelin ETB receptor for BBB disruption. In this study, the effects of BQ788, an ETB receptor antagonist on brain edema and astrocyte-derived factors were examined. As a model of TBI, fluid percussion injury (FPI) was performed on mouse cerebrum. BBB disruption and brain edema were evaluated by Evans blue extravasation and brain water content, respectively. Expressions of astrocyte-derived factors were confirmed by Real-time PCR and immunohistochemistry. To confirm therapeutic efficiencies, intraventricular (i.c.v., 15 nmol/day) or intravenous (i.v., 5 mg/kg/day) administration of BQ788 were performed from 2 to 5 days after FPI. BQ788 ameliorated FPI-induced BBB disruption and brain edema but not affected blood pressure. ETB receptors were mainly distributed in astrocytes and BQ788 appropriately controlled expressions of several astrocyte-derived factors after FPI. Thus, blockade of ETB receptor is expected to be a novel therapeutic strategy for brain edema.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 92 (0), 2-YIA-20-, 2019
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390283659860699264
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- NII Article ID
- 130007813167
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed