Factors affecting tolerance and immunoreactivity of rainbow trout (<I>Oncorhynchus mykiss</I>) to Polyinosinic-polycytidylic acid

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  • Nishikawa Shotaro
    Faculty of Fisheries Sciences, Hokkaido University
  • Nakano Tetsuo
    Technical research laboratories, Kyowa Hakko Bio Co., Ltd. Graduate school of Agriculture, Hokkaido University
  • Kasai Hisae
    Faculty of Fisheries Sciences, Hokkaido University

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Other Title
  • ニジマス（<I>Oncorhynchus mykiss</I>）の Polyinosinic-polycytidylic acid（PIC）投与による免疫賦活作用および同薬剤に対する耐性に及ぼす諸要因
  • Factors affecting tolerance and immunoreactivity of rainbow trout (Oncorhynchus mykiss) to Polyinosinic-polycytidylic acid

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Description

Polyinosinic-polycytidylic acid (PIC), a synthetic double-stranded RNA, is a strong innate immune response inducer. Although it is an innate immune inducer, when administered to some fish species at low temperatures, PIC may be toxic and mortality may occur. Moreover, in mice, immunoreactivity is affected by nucleotide length of PIC. The aim of this study was to demonstrate the effects of body size, water temperature and length of PIC on tolerance and immunoreactivity of rainbow trout to PIC. Tolerance of fish to PIC was better for large fish (145 g) than for small fish (12 g). Furthermore, PIC-induced Mx gene expression when water temperature was high peaked at day 1 and then decreased sharply. When water temperature was low, Mx gene expression lasted longer and high mortality indicated toxicity of PIC. Observations on the effects of length of PIC revealed that Mx gene expression was not significantly related to the length of PIC.

Journal

  • Aquaculture Science

    Aquaculture Science 67 (1), 25-32, 2019

    Japanese Society for Aquaculture Science

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