Involvement of nicotinic acetylcholine receptor-signaling in the impairment of social behavior in the stressed mice

Uchida Mizuki, Kuwana Akimi, Mizoguchi Rina, Ota Erika, Ozaki Norio, Yoshimi Akira, Noda Yukihiro

doi:10.1254/jpssuppl.92.0_1-ss-22

Bibliographic Information

Other Title

ストレス負荷マウスにおける社会性行動障害におけるニコチン性アセチルコリン受容体シグナル伝達の関与

Abstract

[Purpose] We investigated the effect of (-)-nicotine (NIC) on social behaviors in the stressed model mice, and the expression of nicotinic acetylcholine receptor (nAChR) subunits or their intracellular signal-related molecules.[Methods] The adult male C57BL/6J mice were exposed to forced swimming stress for 15 min. They were treated with NIC (0.3 mg/kg s.c.) for 7 days from the next day of exposure to stress. [Results] The stressed mice showed the impairment of social behaviors in the social interaction test and the decreased expression of phosphorylated Akt protein in the hippocampus (HIP). These abnormalities were attenuated by repeated treatment with NIC. The expression of α7 and β2 nAChR subunit proteins was decreased in the HIP of the stressed mice. α7, but not α4β2 nAChR antagonist blocked the ameliorating effect of NIC on behavioral impairment in the stressed mice.[Conclusions] These results suggest that repeated treatment with NIC is useful and effectively for stress-induced depressive-like behaviors. The remission of social behavior impairment by NIC may be mediated via regulating nAChR/Akt signaling in stressed mice.

Journal

Proceedings for Annual Meeting of The Japanese Pharmacological Society

Proceedings for Annual Meeting of The Japanese Pharmacological Society 92 (0), 1-SS-22-, 2019

Japanese Pharmacological Society

Details 詳細情報について

CRID: 1390283659861022336

NII Article ID: 130007812804

DOI: 10.1254/jpssuppl.92.0_1-ss-22

ISSN: 24354953

Web Site: https://www.jstage.jst.go.jp/article/jpssuppl/92/0/92_1-SS-22/_pdf

Text Lang: ja

Data Source

JaLC
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CiNii Articles

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