Transformation of CD5-positive nodal marginal zone lymphoma to diffuse large B-cell lymphoma
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- KOIKE Takashi
- Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine
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- IRIYAMA Noriyoshi
- Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine
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- NAKAGAWA Masaru
- Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine
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- TAKAHASHI Hiromichi
- Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine
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- HAMADA Takashi
- Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine
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- UCHINO Yoshihito
- Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine
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- MIURA Katsuhiro
- Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine
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- HATTA Yoshihiro
- Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine
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- NAKAYAMA Tomohiro
- Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine
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- TAKEI Masami
- Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine
Bibliographic Information
- Other Title
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- びまん性大細胞型B細胞リンパ腫への形質転換をきたしたCD5陽性節性濾胞辺縁帯リンパ腫
- 症例報告 びまん性大細胞型B細胞リンパ腫への形質転換をきたしたCD5陽性節性濾胞辺縁帯リンパ腫
- ショウレイ ホウコク ビマンセイ ダイ サイボウガタ Bサイボウ リンパシュ エ ノ ケイシツ テンカン オ キタシタ CD5 ヨウセイセツセイ ロホウ ヘンエンタイ リンパシュ
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Abstract
<p>Nodal marginal zone lymphoma (NMZL) is a form of nodal B-cell lymphoma exhibiting proliferation of abnormal lymphocytes at the circumference of the mantle zone in the lymph nodes. Although the outcome of patients with this disease is often favorable, we recently encountered a patient with a CD5-positive NMZL who was resistant to chemotherapy. A 67-year-old woman complaining of systemic lymph node swelling was referred to our hospital. After biopsy of the neck lymph node, she was diagnosed with CD5-positive NMZL. Disease progression was revealed after 16 months, and she was initially treated with chemotherapy consisting of rituximab, cyclophosphamide, vincristine, and prednisolone (R-CVP). However, this therapy was ineffective. Subsequent therapy with rituximab and bendamustine also failed to induce remission. A rebiopsy revealed that the NMZL had transformed into a diffuse large B-cell lymphoma. This patient died after 2 years from the initial diagnosis due to lymphoma progression. Cases of CD5-positive NMZL are rare; thus, it is difficult to study the clinical implications of CD5 expression in this disease. Here we describe the current understanding of CD5 expression in NMZL.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 61 (3), 245-250, 2020
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390283659865627520
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- NII Article ID
- 130007821388
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 030383347
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- PubMed
- 32224585
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed